Originally Posted by
Misaki Ki
It still works. Gameguard is just very picky, and seems to block it on various systems due to unknown conflicts.
You can start killing 3rd party services and processes until it works via the process explorer, and eventually you'll get it to hook. (Just be sure you know what you're doing.) Sometimes I had to close RadeonPro, kill and stop the service, start the service, then start RadeonPro to get it to start if it didn't go after clearing a bunch of stuff.
It's a big hassle, but typically it will keep working until a reboot. Enable the FPS counter in RadeonPro as a fast way to see if it works when you start the game.