The upslot does indeed have an impact on the rate for SAF abilities, but if the affix fails you can always "reuse" it since it's innate to the weapon.
That's how I made my Astral 7 slots fodder. (I'm waiting to get another quliphad talis to get that sweet +35 and actually do the affixing)
As for meseta quests, I have no idea if endless quest is really indicated but XQ floors 27 and 47 of the ruins and seabed tower have quite a bit of enemies. Also XQ floor 31 of Forest and Dragon. If you ever get a 50% meseta ticket from the dailies, I recommend those.
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