If i don't use Tweaker to run PSO2 it runs and i can sign into my sega id and everything.

When i use tweaker GameGuard won't update and PSO won't open. It will update when i run PSO2 without tweaker.
GameGuard update failure. Error code 340, 350, 361, 380

Ive deleted the Gameguard folder and let it reinstall.
I have turned off windows defender and anything else that might block it.