It's 20% of your HP in damage within a minute.
With 1k HP, 200 damage (or 201, I'm not sure) damage will break your hero boost.
With 10 points in Hero flash guard, an attack(s) that would normally hit your 1k hp self for 219 damage within a minute without it will not break hero boost for what it's worth.
For the record, I have 1066 HP. My cushion is not that much better.
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