Originally Posted by
Dark Mits
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1. It is best to have all game and tweaker files in a location that is not a System folder. For example "C:/Games/PSO2" instead of directly at "C:/PSO2". It might be good to also give ownership of said folder (and all subfolders) to your user's account instead of System.
2. Make sure that after PSO2 Tweaker is installed, the first thing to do is to select the pso2_bin folder. It may help to also manually adjust all settings in order to ensure that the settings files is properly structured.
3. If the game still does not start, open Task Manager and kill any process like pso2.exe, pso2tweaker.exe etc. Re-run the tweaker and select lower "safe" settings. Do not close Task Manager but monitor if there is CPU and Storage usage when the game is supposedly loading.
There were some other posts earlier in this thread I think where other players also had trouble loading the game after the new graphics update, you could try some of those solutions too.