There are a few noticeable changes
Clicking the clickwheel doesn't pull up the round thing, so one would have to use the left scroll bar. or scroll the wheel. I didn't think I used it much, but its good for skimming long articles
Firefox sees a file, and would often prompt you to open it with a program, or save it; Quicktime accessible stuff is the exception, and is usually opened in firefox. Chrome on the other hand, always makes you save the file somewhere, and doesn't prompt opening the proper program. This just stuck out for me 'cause it would make me save torrents.
There is no stop button. Not in the top, no right click, stop. And right click menu could use a refresh, too.
Chrome doesn't play nicely with facebook, either.
Edit: speaking of noticeable changes, where the hell did my avatar go?
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