Red katana is enough, probably Dio katana at lv 30 is enough too, and I might even be overshooting a bit. you have 24 seconds to kill bosses with greatly reduced HP pool, so provided you can use katana (that is to say press the guren button) you should come out alive from every 1-5 stage, except maybe stage 2, where you may have to *gasp* counter Gunne
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