I had trouble with the game crashing (I still do actually) when I run it for the first time after the pc has been turned on, or recovers from sleep/hibernation. Those started when I updated AMD drivers to their 18.x.x variants.
Google searches indicate that it may be related to Tweaker. Try doing a Gameguard fix from there. If the problem persists, do a clean reinstallation of Tweaker alone (ie. entirely delete all settings and relevant files, then reinstall).
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